A Randomized, Blinded, Double Controlled Study of the Effects of Modified Ma Xing Shi Gan Tang on Mortality, Recovery and Serum Superoxide Dismutase, Glutathione Peroxidase and Malondialdehyde in Chickens with Infectious Bronchitis

نویسنده

  • Yongping Yan
چکیده

Avian infectious bronchitis virus (IBV) causes high mortality and reduced production even in vaccinated birds. The study hypothesis was that a decoction of a Chinese herbal medicine, modified Ma Xing Shi Gan Tang, in the drinking water would reduce mortality and improve recovery and antioxidant capabilities in chickens infected with IBV. Two hundred 15-day-old chickens were randomly divided into 5 groups of 40 each. One group was an untreated control group. Chickens in the other 4 groups were inoculated intranasally with IBV and all developed reduced activity and appetite and respiratory signs within 48 hours. Chickens in 3 groups received 0.6%, 0.4% or 0.2% modified Ma Xing Shi Gan Tang twice daily in the drinking water for 5 days beginning 48 hours after IBV inoculation. Clinical signs were monitored and deaths and recoveries recorded. Serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were evaluated on 6 randomly selected chickens from each group, 5 times over a 3-15 day period and the M±SD statistically compared. Mortality was very significantly (p<0.01) reduced from 42% in the untreated group to 5%, 10% and 27% (0.6%, 0.4% or 0.2% herbs respectively) and affected birds recovered with no adverse effects from the herbs. Chickens receiving 0.6% or 0.4% modified Ma Xing Shi Gan Tang had very significantly (p<0.01) higher serum SOD and GSH-Px and lower serum MDA than untreated IBV chickens. The antioxidant properties of modified Ma Xing Shi Gan Tang make it a novel non-toxic medication for the treatment and potential prevention of IBV infections of chickens. key words: avian, infectious bronchitis, Chinese herbal medicine

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Three Types of Massage on Serum Levels of Malondialdehyde, Superoxide Dismutase and Glutathione Peroxidase after One Session of Exhaustive Exercise in Female Futsal Players

Objective: The production of reactive oxygen species in exercise causes oxidative stress which disturbs the balance of oxidants and antioxidants, causing destructive effects on cells. The present study aims to investigate the effect of three types of massage (Swedish, Russian, Thai) on serum levels of Malondialdehyde (MDA), Glutathione Peroxidase (GPX) and Superoxide Dismutase (SOD) following o...

متن کامل

Effects of Enalapril on growth Performance, Ascites Mortality, Antioxidant Status and Blood Parameters in Broiler Chickens under Cold-Induced Ascites

Six hundred 1-d-old male broilers (Ross 308) were assigned to four experimental groups; each was composed of 5 floor pen replications of 30 birds including control (no enalapril), 15, 30 and 60 ppm enalapril in the drinking water. From d 21 to 49, all the chicks were exposed to low ambient temperature to induce ascites. Mortalities were inspected to determine the cause of death and diagnose of ...

متن کامل

The effects of turmeric supplementation on antioxidant status, blood gas indices and mortality in broiler chickens with T(3)-induced ascites.

1. A total of 320 one-day-old Ross male broiler chickens were used to investigate the effects of 0·0, 2·5, 5·0 and 7·5 g/kg turmeric rhizome powder (TRP) in the diet, on antioxidant status, biochemical gas indices and mortality in broiler chickens with triiodothyronine (T(3)) induced ascites. 2. The TRP supplementation had no effect on blood pH, pO(2) or pCO(2) during the whole period of study....

متن کامل

Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers

To assess relationships between xanthine oxidase (XOD) and nephropathogenic infectious bronchitis virus (NIBV) infection, 240 growing layers (35 days old) were randomly divided into two groups (infected and control) of 120 chickens each. Each chicken in the control and infected group was intranasally inoculated with 0.2 mL sterile physiological saline and virus, respectively, after which serum ...

متن کامل

Effects of zinc oxide nanoparticles on antioxidant status, serum enzymes activities, biochemical parameters and performance in broiler chickens

This research was conducted to investigate the effect of zinc oxide Nanoparticles (nano-ZnO) in diets on the performance, antioxidant status, enzymes activity and some hematological parameters of broiler chickens. A total of 600 one–day-old male Ross 308 broilers were allocated to four treatment groups with five replications of 30 each from day 1 to 42 day of age. The birds were continuously di...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016